Salud
Un compuesto de la planta amancay podría ser un aliado contra la enfermedad de Chagas
Un grupo de investigadores científicos de Argentina, Costa Rica y España, que forman parte de la red RENATEC del Programa Iberoamericano de Ciencia y Tecnología para el Desarrollo (CYTED) identificó que la candimina, un alcaloide extraído de una planta silvestre, podría ser un compuesto para actuar contra un blanco molecular del parásito que es responsable de la enfermedad.
El compuesto pertenece a una especie que popularmente se conoce como “amancay” o “amarilis”. Aunque vale tener en cuenta que hay otras especies de plantas que reciben también ese nombre común.
“En estudios previos, habíamos encontrado que la candimina tenía efectos frente al parásito. Ahora, con el uso del modelado molecular computacional, pudimos determinar un posible mecanismo predictivo sobre cómo actúa la candimina para matar al parásito. Bloquea una proteína clave para mantener al parásito con vida”, explicó la doctora en bioquímica Gabriela Egly Feresin, investigadora del CONICET y la Universidad Nacional de San Juan en Argentina.
A partir de los resultados, es necesario avanzar con estudios preclínicos y clínicos. La meta es favorecer el diseño de terapias más seguras. El trabajo fue publicado en la revista Molecular Diversity. Otros integrantes del equipo pertenecen a la Universidad de Barcelona y la Universidad de Costa Rica.
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